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Antioxidant Activity of Bawang Lanang (Allium sativum) as a Natural Product-Based Drug Candidate: A Potential Pharmacological Review
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Vol. 5 No. 1 (2025) • Articles

Antioxidant Activity of Bawang Lanang (Allium sativum) as a Natural Product-Based Drug Candidate: A Potential Pharmacological Review

Published 2025-06-30
Shafa Auliya , Saeful Amin
Jurnal Farmasi Klinik dan Sains , Vol. 5, No. 1 (2025) , pp. 25-30 , Published: 2025-06-30
1 Program Studi Farmasi, Fakultas Farmasi, Universitas Bakti Tunas Husada, Tasikmalaya

Abstract

Developing natural product-based drugs with antioxidant activity represents a promising field in medicinal chemistry. This research aims to examine the potential of bawang lanang (Allium sativum) as a source of natural antioxidants that can be developed into drug candidates. The review method employs a systematic analysis approach to research related to the antioxidant activity of bawang lanang, biochemical mechanisms, and development prospects in medicinal chemistry. The results showed that the ethanol extract of bawang lanang bulbs has strong antioxidant activity with an ICâ‚…â‚€ value of 13.85 ppm. In comparison, the ethyl acetate fraction exhibits higher activity with an ICâ‚…â‚€ of 7.27 ppm. Phytochemical analysis identified the presence of flavonoids, saponins, and tannins that contribute to antioxidant activity. The antioxidant potential of bawang lanang is estimated to derive from organosulfur components, especially allicin and its derivatives, which can scavenge DPPH free radicals. Structural modification of bawang lanang bioactive compounds through medicinal chemistry approaches can potentially improve bioavailability and reduce side effects. In conclusion, bawang lanang has great prospects for development as an antioxidant drug through medicinal chemistry approaches with optimization of active compound structures, pharmacokinetic studies, and toxicity evaluation.

Keywords

Bawang lanang antioxidant DPPH medicinal chemistry drug development
Copyright (c) 2025 Shafa Auliya, Saeful Amin

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References

  1. Amin, S. (2015a). UJI AKTIVITAS ANTIOKSIDAN DAN TELAAH FITOKIMIA Sargassum crassifolium J. G. Agardh. RUMPUT LAUT ALAM ASAL PANTAI BATU KARAS KECAMATAN CIJULANG KABUPATEN CIAMIS. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-Ilmu Keperawatan, Analis Kesehatan Dan Farmasi, 14(1), 1. https://doi.org/10.36465/jkbth.v14i1.131
  2. Amin, S. (2015b). UJI AKTIVITAS ANTIOKSIDAN UMBI BAWANG LANANG (Allium sativum) TERHADAP RADIKAL BEBAS DPPH (1,1-DIFENIL-2-PIKRIHIDRAZIL. Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-Ilmu Keperawatan, Analis Kesehatan Dan Farmasi, 13(1), 124–129. https://doi.org/10.36465/jkbth.v13i1.23
  3. Andarwulan, N., Kurniasih, D., Apriady, R., Rahmat, H., Roto, A., & Bolling, B. (2012). Polyphenols, carotenoids, and ascorbic acid in underutilized medicinal vegetables. Journal of Functional Foods, 4, 339–347. https://doi.org/10.1016/j.jff.2012.01.003
  4. Arnanda, Q. P., & Nuwarda, R. F. (2019). Penggunaan Radiofarmaka Teknisium-99M Dari Senyawa Glutation dan Senyawa Flavonoid Sebagai Deteksi Dini Radikal Bebas Pemicu Kanker. Farmaka Suplemen, 14(1), 1–15. https://jurnal.unpad.ac.id/farmaka/article/view/22071
  5. Azizah, Z., Yani, P., & Yetti, R. D. (2020). Antioxidant Activity Ethanol Extract of Garlic (Allium sativum L.) and Black Garlic. International Journal of Research and Review (Ijrrjournal.Com), 7(9), 94.
  6. Deng, Y., Ho, C., Lan, Y., Xiao, J., & Lu, M. (2023). Bioavailability, Health Benefits, and Delivery Systems of Allicin: A Review. Journal of Agricultural and Food Chemistry, 71. https://doi.org/10.1021/acs.jafc.3c05602
  7. Germain, E., Chevalier, J., Steib, M., Siess, M. H., Germain, E., Chevalier, J., Steib, M., Siess, M. H., & Teyssier, C. (2020). In vitro and ex vivo metabolism of diallyl disulfide , a characteristic sulfur compound of garlic , in rat . To cite this version : HAL Id : hal-02829637.
  8. Kashuri, M. (2024). Natural Medicine for Natural Defence.
  9. Kurnia, D., Ajiati, D., Heliawati, L., & Sumiarsa, D. (2021). Antioxidant Properties and Structure-Antioxidant Activity. Molecules, 26(23), 7175.
  10. Lassalas, P., Gay, B., Lasfargeas, C., James, M. J., Tran, V., Vijayendran, K. G., Brunden, K. R., Kozlowski, M. C., Thomas, C. J., Smith, A. B., Huryn, D. M., & Ballatore, C. (2016). Structure Property Relationships of Carboxylic Acid Isosteres. Journal of Medicinal Chemistry, 59(7), 3183–3203. https://doi.org/10.1021/acs.jmedchem.5b01963
  11. Liang, N., & Kitts, D. D. (2014). Antioxidant property of coffee components: assessment of methods that define mechanisms of action. Molecules (Basel, Switzerland), 19(11), 19180–19208. https://doi.org/10.3390/molecules191119180
  12. Lindawati, N. Y., & Hartono, H. (2019). Optimasi Kapsul Bawang Putih (Allium sativum Linn) sebagai Terapi Alternatif Pengobatan TBC. Jurnal Farmasi (Journal of Pharmacy), 2(1), 19. https://doi.org/10.37013/jf.v2i1.16
  13. Nurullita, U., & Irawati, E. (2022). Perbandingan Aktivitas Antioksidan Bahan Alami Dan Bahan Sintetis (Study Pada Kayu Secang dan Vitamin C). Jurnal MIPA, 11(2), 51. https://doi.org/10.35799/jm.v11i2.40089
  14. Plowright, A. T., Ottmann, C., Arkin, M., Auberson, Y. P., Timmerman, H., & Waldmann, H. (2017). Joining Forces: The Chemical Biology–Medicinal Chemistry Continuum. Cell Chemical Biology, 24(9), 1058–1065. https://doi.org/10.1016/j.chembiol.2017.05.019
  15. Prasonto, D., Riyanti, E., & Gartika, M. (2017). UJI AKTIVITAS ANTIOKSIDAN EKSTRAK BAWANG PUTIH (Allium sativum). Dental Journal, 4, 122–128.
  16. Siswandono. (2016). KIMIA MEDISINAL 1, Edisi Kedua, 2016.
  17. Speisky, H., Shahidi, F., de Camargo, A. C., & Fuentes, J. (2022). Revisiting the Oxidation of Flavonoids: Loss, Conservation or Enhancement of Their Antioxidant Properties. Antioxidants, 11(1), 1–28. https://doi.org/10.3390/antiox11010133
  18. Wahdaningsih, S., Untari, E. K., & Robiyanto, -. (2019). Acute Toxicity Test of Ethanolic Extract of Dayak Onion Leaves (Eleutherine americana Merr.) Toward Wistar Female Rats Using OECD 425 Method. Dhaka University Journal of Pharmaceutical Sciences, 18(2), 171–177. https://doi.org/10.3329/dujps.v18i2.43259
  19. Zalukhu, M. L., Phyma, A. R., & Pinzon, R. T. (2016). Proses Menua , Stres Oksidatif , dan Peran Antioksidan. 43(10), 733–736.
  20. Zuraida, Sulistiyani, Sajuthi, D., & Suparto, I. H. (2017). Fenol, Flavonoid, dan Aktivitas Antioksidan Pada Ekstrak Kulit Batang Pulai. 4(0216–4329), 211–219.

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