Loading
CLINICAL OBSERVATION OF MALONDIALDEHYDE FREE RADICAL COMPOUND LEVELS IN URINE SAMPLES OF SMOKERS AND NON SMOKERS GIVEN JUICE WATERMELON (Citrullus Lanatus)
##common.pageHeaderLogo.altText##
Vol. 5 No. 2 (2025) • Articles

CLINICAL OBSERVATION OF MALONDIALDEHYDE FREE RADICAL COMPOUND LEVELS IN URINE SAMPLES OF SMOKERS AND NON SMOKERS GIVEN JUICE WATERMELON (Citrullus Lanatus)

Published 2025-12-31
NUR MASYITHAH ZAMRUDDIN , Kadek Ayu Dwi Septiani , Maria Almeida , Arman Rusman , Fahriani Istiqamah Jafar , Herman Herman
Jurnal Farmasi Klinik dan Sains , Vol. 5, No. 2 (2025) , pp. 18-23 , Published: 2025-12-31
1 Universitas Mulawarman

Abstract

Malondialdehid (MDA) merupakan biomarker stres oksidatif akibat keberadaan radikal bebas dalam tubuh. Penelitian ini bertujuan untuk mengetahui gambaran kadar MDA urin dan asam urat pada responden perokok dan non perokok dan mengetahui perubahan kadar MDA urin dan asam urat pada responden perokok dan non perokok yang diberikan minuman antioksidan jus buah semangka (Citrullus lanatus). Metode penelitian yang digunakan adalah pre-post test design. Hasil penelitian menunjukkan bahwa kadar MDA urin pada perokok aktif dan bukan perokok sebelum pemberian jus semangka adalah 2,666 nmol/mL dan 1,506 nmol/mL, sedangkan hasil penelitian setelah pemberian jus semangka pada hari ke-7 pada responden adalah 0,799 nmol/mL dan 0,539 nmol/mL. Sedangkan kadar asam urat awal masing-masing responden sebesar 7,5 mg/dL dan 6,6 mg/dL dan hasil penelitian setelah pemberian jus pada hari ke-7 kepada responden sebesar 6,1 mg/dL dan 5,7 mg/dL. Pada hasil analisis statistik menggunakan uji-t didapatkan nilai p<0,05 pada kadar MDA urin pada perokok dan bukan perokok, nilai p>0,05 pada kadar asam urat perokok dan nilai p<0,05 pada kadar asam urat pada bukan perokok. Jadi dapat disimpulkan bahwa ada pengaruh pemberian jus semangka terhadap kadar MDA urin masing-masing responden tetapi tidak terhadap kadar asam urat

Keywords

Malondialdehid Semangka Radikal bebas
Copyright (c) 2025 NUR MASYITHAH ZAMRUDDIN, Kadek Ayu Dwi Septiani, Maria Almeida, Arman Rusman, Fahriani Istiqamah Jafar, Herman Herman

The copyright of the published manuscript belongs to the Author, while JFKS is given the right to publish and reproduce in part or in whole. All articles published by JFKS are open access content under the Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license.

Authors who publish with this journal agree to the following terms:

  1. The author retains the copyright and the journal publishing rights simultaneously by granting a license under the Creative Commons Attribution License which allows others to share the work with a statement of authorship of the work and initial publication in this journal.
  2. Authors are allowed and permitted to save their articles on institutional repositories or on their websites, as well as other online repositories after articles are published on JFKS.

Downloads

Download data is not yet available.

References

  1. WHO WHO Report on The Global Tobacco Epidemic. 2023.
  2. Benowitz NL; Hua Fu Smoking & Occupational Health 2007.
  3. Sampurna; Masyhudi; Alterina Mydriati Sita P; Siti Thomas Z; Arrizki Azka P Peningkatan Kadar Malondialdehid (MDA) Akibat Paparan Asap Rokok. Jurnal Penelitian Kesehatan Suara Forikes 2023, 14, 781–783, doi:http://dx.doi.org/10.33846/sf14423.
  4. Lorenza, D. Determination of Malondialdehyde (MDA) Levels In The Saliva of Man Smokers Age 45-59 Years; 2025;
  5. Prahasta, A. Agribisnis Semangka; Pustaka Grafika: Bandung, 2009;
  6. Tahir, M.; Cahya, A.; Widiastuti, H. Uji Aktivitas Antioksidan Buah Semangka (Citrullus Lanatus) Dengan Metode FRAP. As-Syifaa 2016, 08, 31–38.
  7. Devaraj, S.; Mathur, S.; Basu, A.; Aung, H.H.; Vasu, V.T.; Meyers, S.; Jialal, I. A Dose-Response Study on the Effects of Purified Lycopene Supplementation on Biomarkers of Oxidative Stress; 2009;
  8. Moneim, A.; Sulieman, E. Proximae Chemical Composition Of Watermelon (Citrullus Vulgaris) The Effect of Malting Condition and Mashing Method on Production of Non-Alcoholic Sorghum Beverage View Project;
  9. Moussa, TarekA.A.; Albishri, H.; Almaghrabi, O. Characterization and Chemical Composition of Fatty Acids Content of Watermelon and Muskmelon Cultivars in Saudi Arabia Using Gas Chromatography/Mass Spectroscopy. Pharmacogn Mag 2013, 9, 58, doi:10.4103/0973-1296.108142.
  10. Irma Septiana, L.; Wulandhari, S.; Winangun, I. Differences in Malondialdehyde (MDA) Levels in Community Acquired Pneumonia (CAP) Patients in Smokers and Non-Smokers at Gerung Hospital. Nusantara Hasana Journal 2023, 2, 40–53.
  11. Naz, A.; Sadiq Butt, M.; Sultan, M.T.; Muhammad, M.; Qayyum, N.; Shahid Niaz, R. Watermelon Lycopene And Allied Health Claims; 2014; Vol. 13;.
  12. Widhiani, N.P.V.; Widiastuti, I.A.E.; Zubaidi, F.F. The Difference in Malondialdehyde (MDA) Levels among Normoweight, Overweight, and Obesity in Student of Medicine Program Faculty of Medicine, Mataram University. Jurnal Biologi Tropis 2023, 23, 595–599, doi:10.29303/jbt.v23i3.5429.
  13. Putri Tarigan, A.; Retno Gunarti, D.; Sunardi, D. Peran Pemeriksaan Malondialdehid Sebagai Penanda Stres Oksidatif Pada Anak Stunting: 2024
  14. Harliansyah; Rozaan Fadlurrahman Andrew Penentuan Kadar Malondialdehid (MDA) Pada Saliva Wanita Perokok Usia 26-35. Majalah Kesehatan PharmaMedika 2018, 78.
  15. Zainuri, M.; Wanandi, S.I.; Litbangkes, B.; Ri, K. Aktivitas Spesifik Manganese Superoxide Dismutase (Mnsod) Dan Katalase Pada Hati Tikus Yang Diinduksi Hipoksia Sistemik: Hubungannya Dengan Kerusakan Oksidatif Spesific; 2012; Vol. 22;.
  16. Jitmau AM; Rondonuwu FS; Semangun H Likopen Pelindung Fungsi Indera Penglihatan, Peraba,. 2010.
  17. Sulistyaning, A.; Farida, F.; Sari, H. The Consumption of Yellow Watermelon-Plantain Juice before Anaerobic Exercise Improves Blood Glucose and Suppresses Oxidative Stress Formation in Rats. Open Access Maced J Med Sci 2022, 10, 396–401, doi:10.3889/oamjms.2022.8553.
  18. Ajiboye, B.O.; Shonibare, M.T.; Oyinloye, B.E. Antidiabetic Activity of Watermelon (Citrullus Lanatus) Juice in Alloxan-Induced Diabetic Rats. J Diabetes Metab Disord 2020, 19, 343–352, doi:10.1007/s40200-020-00515-2.
  19. Hanna, B.E.; Hamed, J.M.; Touhala, L.M. Serum Uric Acid in Smokers; 2008; Vol. 23;.
  20. Bazabang, S.A.; Makena, W.; Onimisi, O.B.; Rilwan, H.B.; Buba, H.S.; Jerome, V.K.; Yohana, A. Flavonoid-Rich Extract from Citrullus Lanatus (Watermelon) Seed Attenuated Ethanol-Induced Kidney Injury in Wistar Rats. Pharmacological Research - Modern Chinese Medicine 2023, 7, doi:10.1016/j.prmcm.2023.100236.

Similar Articles

You may also start an advanced similarity search for this article.

Home Current Archives New Journal Search